Uncovering Origins of Disparities in Breast Cancer Survival
Our long-term goal is to ensure that young and black women fully benefit from the many advances made in breast cancer treatment and to ultimately eliminate survival disparities. Designing effective interventions to reduce age and race-related disparities in breast cancer survival requires that we identify modifiable causes. Our overall objective of this project is to evaluate the role of pathologic complete response to neoadjuvant chemotherapy (pCR), age, and race in breast cancer survival and to investigate a potential mechanism for previously observed disparities in HR+ breast cancer, adherence and persistence with endocrine therapy.
The central hypothesis of our research is that black and young women experience worse outcomes from less aggressive tumor subtypes and this is partially due to lower adherence to, and persistence with, endocrine therapy. The rationale for the proposed research is that the knowledge gained can identify targets for intervention to eliminate disparities including interventions to improve adherence and persistence.